CD163 antigen (scavenger receptor cysteine-rich type 1 protein M130, hemoglobin scavenger receptor, M130)

Function

• acute phase-regulated receptor
• clearance & endocytosis of hemoglobin/haptoglobin complexes by macrophages
• uptake & recycling of iron
• induces a cascade of intracellular signals that involves tyrosine kinase-dependent Ca+2 mobilization, IP3 production & secretion of IL6 & CSF1

Compartment

• membrane
• soluble form (sCD163) is produced by proteolytic shedding

Expression

• induced by anti-inflammatory mediators
  • glucocorticoids, IL6, IL10
• suppressed by proinflammatory
  • lipopolysaccharide, IGN-gamma, TNF-alpha

Pathology

sCD163 is a disease marker of inflammatory conditions

More general terms

• CD antigen
• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/605545
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9332
• UniProt: http://www.uniprot.org/uniprot/Q86VB7.html