CD73 (ecto-5'nucleotidase, 5-prime-ribonucleotide phosphohydrolase, NT5E)

Function

• catalyzes conversion of purine 5-prime mononucleotides to nucleosides at neutral pH
• hydrolyzes extracellular nucleotides into membrane permeable nucleosides

Cofactor: Zn+2

Compartment

cell membrane, lipid-anchor, GPI-anchor

Expression

• B-cell & T-cell subsets
• endothelial cells
• follicular dendritic cells
• epithelial cells

Pathology

• decreased activity in B cell CLL
• high levels poor prognostic factor in leukemias/lymphomas

Notes

• marker of lymphocytic differentiation
• other forms of 5'nucleotidases exist in cytoplasm & lysosomes & can be distinguished by substrate affinities

More general terms

• 5'nucleotidase (5'-ribonucleotide phosphohydrolase)
• glypiated protein
• oligomerizing protein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4907
• UniProt: http://www.uniprot.org/uniprot/P21589.html
• OMIM: https://mirror.omim.org/entry/129190