B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B, radiation-induced tumor suppressor gene 1 protein, hRit1, COUP-TF-interacting protein 2, BCL11B, CTIP2, RIT1)
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Function
- tumor-suppressor protein
- role in P53-signaling pathway (putative)
- regulates both differentiation & survival during thymocyte development
- represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element
- interacts with TFCOUP1, SIRT1, ARP1 & EAR2
Structure
- contains 6 C2H2-type zinc fingers
Compartment
Alternative splicing
named isoforms=2
Expression
highly expressed in brain
Pathology
- role in T-cell lymphomas
- highly expressed in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma
More general terms
- bcl protein (B-cell leukemia/lymphoma protein)
- zinc finger protein
- anti-oncoprotein (tumor suppressor protein)
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9C0K0.html
- ↑ Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/BCL11BID392.html