KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1, SLM-1, hSLM-1, KHDRBS2, SLM1)

Function

• RNA-binding protein
• role in the regulation of alternative splicing & influences mRNA splice site selection & exon inclusion
• phosphorylation by FYN inhibits its ability to regulate splice site selection
• induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer
• may function as an adapter protein for Src kinases during mitosis.
• binds both poly(A) & poly(U) homopolymers
• phosphorylation by PTK6 inhibits its RNA-binding ability (putative)
• self-associates to form homo-oligomers
• interacts with RBMX, SAFB, SFRS9 & YTHDC1
• found in a complex with KHDRBS1, KHDRBS2 & KHDRBS3
• interacts with SH3 domains of FYN & PLCG1
• interacts with SH2 domains of FYN, GRAP2, PLCG1 & RASA1 (putative)
• methylated
• tyrosine phosphorylated by FYN, PTK6 & SRC
• tyrosine phosphorylated by SRC during mitosis (putative)

Structure

• belongs to the KHDRBS family
• contains 1 KH domain

Compartment

nucleus (putative)

Expression

• expressed in brain, lung, kidney & small intestine > placenta, liver, spleen, thymus, ovary & colon

More general terms

• nuclear protein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5VWX1.html