leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1, TAR RNA-interacting protein, GC-binding factor 2, LRRFIP1, GCF2, TRIP)

Function

• transcriptional repressor
• preferentially binds to GC-rich consensus sequence (5'-AGCCCCCGGCG-3')
• regulates expression of TNF, EGFR & PDGFA (putative)
• controls smooth muscle cell proliferation following artery injury through PDGFA repression (putative)
• binds double-stranded RNA (putative)
• interacts with FLI

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• widely expressed in fetal tissues

More general terms

• RNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603256
• UniProt: http://www.uniprot.org/uniprot/Q32MZ4.html