platelet endothelial aggregation receptor 1 (hPEAR1, multiple epidermal growth factor-like domains 12, multiple EGF-like-domains 12, MEGF12, PEAR1)

Function

• when overexpressed, diminishes the number of both early & late non-adherent myeloid progenitor cells (putative)
• interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation
• phosphorylated in the intracellular domain on tyrosine residues (putative)
• phosphorylated on tyrosine residues by SRC
• tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP & thrombin & platelet-platelet contacts but not after platelet activation
• tyrosine phosphorylation enhances its association with SHC1 & SHC2

Structure

• belongs to the MEGF family
• contains 9 EGF-like domains
• contains 1 EMI domain

Compartment

• membrane (putative)
• detected on the cell surface in resting platelets

Expression

• expressed in umbilical vein endothelial cells & platelets (at protein level)
• expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery & vein, megakaryocytes, osteoblasts, heart muscle & erythroid cells
• weakly expressed in peripheral blood leukocytes & macrophages

More general terms

• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5VY43.html