emelin-1; elastin microfibril interface-located protein 1; elastin microfibril interfacer 1 (EMILIN1, EMI)

Function

• anchoring smooth muscle cells to elastic fibers
• regulation of vessel assembly
• cell adhesive capacity
• interacts with EMILIN2

Structure

• homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing nucleation of the triple helix & then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds
• contains 1 C1q domain
• contains 1 collagen-like domain
• contains 1 EMI domain

Compartment

• secreted, extracellular matrix
• interface between amorphous elastin & microfibrils

Expression

• distributed in tissues where resilience & elastic recoil are prominent
• expressed in small intestine, aorta, lung, uterus, appendix (adult) & in fetal spleen, kidney, lung, & heart > adult liver, ovary, colon, stomach, lymph node, spleen > adult heart, bladder, prostate, adrenal gland, mammary gland, placenta & kidney
• not expressed in adult skeletal muscle or brain
• deposition precedes the appearance of elastin, simultaneous with that of fibrillin 1

More general terms

• emilin; elastin microfibril interface located protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11117
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11117
• OMIM: https://mirror.omim.org/entry/130660
• UniProt: http://www.uniprot.org/uniprot/Q9Y6C2.html