emelin-2; elastin microfibril interface-located protein 2; elastin microfibril interfacer 2; protein FOAP-10 (EMILIN2)

Function

• anchoring smooth muscle cells to elastic fibers
• regulation of vessel assembly
• cell adhesive capacity
• interacts with EMILIN1

Structure

• homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing nucleation of the triple helix & then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds
• contains 1 C1q domain
• contains 1 collagen-like domain
• contains 1 EMI domain

Compartment

• secreted, extracellular matrix
• interface between amorphous elastin & microfibrils

Expression

• expressed in fetal heart, adult lung > peripheral leukocytes, placenta, spinal cord > fetal brain, spleen, thymus lung; adult heart, aorta, testis, bone marrow, small intestine, thymus, lymph node, appendix

More general terms

• emilin; elastin microfibril interface located protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84034
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84034
• OMIM: https://mirror.omim.org/entry/608928
• UniProt: http://www.uniprot.org/uniprot/Q9BXX0.html