SHC-transforming protein 2; protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2 (SHC2, SCK, SHCB)

Function

• signaling adapter that couples activated growth factor receptors to signaling pathway in neurons
• involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (putative)
• phosphorylated on Tyr by the Trk receptors
• interacts with Trk receptors (phospho-Tyr-dependent)
• once activated, binds to GRB2

Structure

• the PID domain mediates binding to the TrkA receptor
• contains 1 PID domain
• contains 1 SH2 domain

Expression

• expressed in brain
• expressed at high level in the hypothalamus
• expressed at low level in the caudate nucleus

More general terms

• Shc proto-oncogene protein (Shc transforming protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25759
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25759
• OMIM: https://mirror.omim.org/entry/605217
• UniProt: http://www.uniprot.org/uniprot/P98077.html