Fc receptor-like protein 6 (FcR-like protein 6, FcRL6, Fc receptor homolog 6, FcRH6, IFGP6, FCRL6, FCRH6)

Function

• interacts with PTPN11
• phosphorylated on Tyr, inducing association with PTPN11

Structure

• contains 3 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 ITIM motif, phosphorylated ITIM motif has role in PTPN11 binding

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• expressed by cytolytic cells including NK cells, effector & effector-memory CD8+ T-cells

Pathology

• expression among T-cells is greatly expanded in HIV-1 infected individuals, & includes not only effector & effector-memory CD8+ T-cells but also populations of CD4+ T-cells

More general terms

• immunoglobulin superfamily protein
• phosphoprotein
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6DN72.html