APBB1-interacting protein 1 (amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Rap1-GTP-interacting adapter molecule, RIAM, Proline-rich EVH1 ligand 1, PREL-1, proline-rich protein 73, retinoic acid-responsive proline-rich protein 1, RARP-1, APBB1IP, PREL1, RARP1, RIAM)
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Function
- role in signal transduction from Ras activation to actin cytoskeletal remodelling
- suppresses insulin-induced promoter activities through AP1b& SRE
- mediates Rap1-induced adhesion
- interacts, through the N-terminal Pro-rich region, with WW domain of APBB1
- interacts with RAP1A, PFN1, VASP & ENAH
Structure
- belongs to the MRL family
- contains 2 Pro-rich regions required for suppression of AP1 transcription activity
- contains 1 PH domain
- contains 1 Ras-associating domain
Compartment
- cell membrane
- colocalizes with ENA/VASP proteins at lamellipodia tips & focal adhesions, & F-actin at the leading edge
- at the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns-5-Phosphate & PtdIns-3-Phosphate - necessary for efficient interaction of RA domain with Ras-GTPases
Expression
- widely expressed
- high expression in thymus, spleen, lymph node, bone marrow & peripheral leukocytes
- induced by all-trans-retinoic acid