leucine-rich repeats & immunoglobulin-like domains protein 1 (LRIG1, LIG1)

Function

• negative regulator of signaling by receptor tyrosine kinases via receptor ubiquitination & intracellular degradation
• interacts with EGFR/ERBB1, ERBB2, ERBB3 & ERBB4
  • LRRs & the Ig-domains are each sufficient for EGFR/ERBB1 binding

Structure

• contains 3 Ig-like C2-type domains (immunoglobulin-like)
• contains 17 LRR repeats (leucine-rich repeats)

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• induced by EGF

More general terms

• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/608868
• UniProt: http://www.uniprot.org/uniprot/Q96JA1.html