Fas apoptotic inhibitory molecule 3; regulator of Fas-induced apoptosis (FAIM3, TOSO)

Function

• role in the immune system processes (putative)
• protects cells from FAS-, TNF alpha- & FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 & BCLXL
• activates an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream (putative)
• may inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation

Structure

• contains 1 Ig-like domain (immunoglobulin-like) required for the anti-apoptotic activity

Compartment

membrane

Expression

• expressed in lymph nodes, peripheral blood leukocytes, lung, thymus, kidney
• very weak expression detected in spleen, liver, heart, salivary gland
• expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, & Reh cells
• no expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells & Hela cells
• induced by T-cell activation

Notes

-'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life & eternal youth

More general terms

• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9214
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9214
• OMIM: https://mirror.omim.org/entry/606015
• UniProt: http://www.uniprot.org/uniprot/O60667.html