Fas apoptotic inhibitory molecule 2; protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2 (FAIM2 KIAA0950 LFG LFG2 NMP35 TMBIM2)

Function

• antiapoptotic protein
  • protects cells uniquely from Fas-induced apoptosis
• regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation
• may play a role in cerebellar development by affecting cerebellar size, internal granular layer thickness, & Purkinje cell development
• interacts with FAS/TNFRSF6 & BAX

Structure

belongs to the BI1 family, LFG subfamily

Compartment

• cell membrane; multi-pass membrane protein (putative)
• membrane raft
• cell junction, synapse, postsynaptic cell membrane (putative)

Expression

• widely expressed
• expressed at high levels in the brain especially in the hippocampus

Pathology

• highly expressed in breast carcinoma tissues
  • enhanced expression correlates with the grade of the tumor in primary breast tumors (at protein level)
• regulated by the AKT1/LEF1 pathway in breast cancer cell lines

More general terms

• transmembrane 7c protein
• glycoprotein

Additional terms

• apoptosis
• CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23017
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23017
• OMIM: https://mirror.omim.org/entry/604306
• UniProt: http://www.uniprot.org/uniprot/Q9BWQ8.html