Bax inhibitor 1; BI-1; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6 (TMBIM6, BI1, TEGT)

Function

• suppressor of apoptosis
  • in mammalian cells, Bl-1 inhibits apoptosis induced by bax, growth factor deprivation, etoposide & staurosporine, but not fas.
• interacts with BCL2 & BCL2L1/BCLX
  • BI-1 can interact with bcl-2 & bcl-XL but not bax or bak

Structure

• belongs to the BI1 family
• BI-1 is predicted to contain 6 or 7 transmembrane domains
• found to be essentially identical to TEGT (testis enhanced gene transcript)

Compartment

• membrane (potential)

Expression

• highly abundant in testis

More general terms

• transmembrane 6 protein
• anti apoptotic protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7009
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7009
• OMIM: https://mirror.omim.org/entry/600748
• UniProt: http://www.uniprot.org/uniprot/P55061.html