KiSS-1 receptor (KiSS-1R, kisspeptins receptor, metastin receptor, G-protein coupled receptor 54, hypogonadotropin-1, hOT7T175, KISS1R, AXOR12, GPR54, OT7T175)
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Function
- receptor for metastin
- inhibits cell proliferation & cell migration
- cell cycle arrest & induction of apoptosis in malignant cells
- role in normal gonadotropin-releasing hormone physiology & in puberty
- regulation of gonadotropic axis at puberty & in adulthood
- regulation & fine-tuning of trophoblast invasion generated by the trophoblast
- coupling to phospholipase C & intracellular Ca+2 release via pertussis toxin-insensitive Gq proteins
Structure
- belongs to the G-protein coupled receptor 1 family
Compartment
Expression
- expressed in the pancreas, placenta, spinal cord > peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands, lymph nodes
- in adult brain, expressed in superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons, amygdala, hypothalamus, pituitary
Pathology
- defects in KISS1R are a cause of
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q969F8.html
- ↑ protein Spotlight; Tintin's blight - Issue 58 of may 2005 http://www.expasy.org/spotlight/back_issues/sptlt058.shtml
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=KISS1R