poliovirus receptor; nectin-like protein 5; necl-5; CD155 (PVR, PVS)
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Function
- mediates NK cell adhesion & triggers NK cell effector functions
- binds 2 different NK cell receptors: CD96 & CD226
- these interactions
- accumulate at the cell-cell contact site, leading to formation of a mature immunological synapse between NK cell & target cell
- may trigger adhesion & secretion of lytic granules & IFN-gamma & activate cytoxicity of activated NK cells
- may also promote NK cell-target cell modular exchange, & PVR transfer to the NK cell
- can form trans-heterodimers with PVRL3/nectin-3.
- extracellular domain interacts with VTN, CD226 & CD96
- cytoplasmic domain interacts with DYNLT1
- interacts with HHV-5 UL141
Structure
- belongs to the nectin family
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like); V-type domain is necessary & sufficient for virus binding & uptake
Compartment
- isoforms alpha, delta: cell membrane
- isoforms beta, gamma: secreted
Alternative splicing
named isoforms=4
Expression
- transcriptionally regulated by SHH
Pathology
- role in mediating tumor cell invasion & migration
- PVR transfer to the NK cell may be important in tumor cells expressing a lot of PVR, & may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion
- receptor for poliovirus attachment to target cells
- may play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1; this interaction would drive the virus-containing vesicle to the axonal retrograde transport
- interacts with poliovirus capsid composed of VP1, VP2 & VP3, mainly through VP3
Notes
The V-type domain is necessary & sufficient for virus binding & uptake
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P15151.html
- ↑ Protein Spotlight; The accidental crippler
Issue 75 of October 2006 http://www.expasy.org/spotlight/back_issues/sptlt075.shtml