T-cell surface protein tactile; T cell-activated increased late expression protein; cell surface antigen CD96 (CD96)
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Function
- may play role in adhesive interactions of activated T cells & NK cells during the late phase of the immune response promotes NK cell-target adhesion by interacting with PVR present on target cells
- may function at a time after T & NK cells have penetrated the endothelium using integrins & selectins, when they are actively engaging diseased cells & moving within areas of inflammation
- interacts with PVR
Structure
- homodimer; disulfide-linked.
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 2 Ig-like V-type domain (immunoglobulin-like)
Compartment
membrane; single-pass type 1 membrane protein
Alternative splicing
named isoforms=2
Expression
- expressed on normal T-cell lines & clones, & some transformed T-cells, but no other cultured cell lines tested
- expressed at very low levels on activated B-cells
- expressed at low levels on peripheral T-cells & is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus
Pathology
- chromosomal translocation t(3;18)(q13.13;q12.1) involving CD96 is associated with C syndrome
- defects in CD96 are a cause of C-like syndrome
More general terms
References
Database
- UniProt: http://www.uniprot.org/uniprot/P40200.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10225
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10225
- OMIM: https://mirror.omim.org/entry/211750
- OMIM: https://mirror.omim.org/entry/605039
- OMIM: https://mirror.omim.org/entry/606037