Na+ channel protein type 9 subunit alpha; Na+ channel protein type IX subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.7; neuroendocrine Na+ channel; hNE-Na; peripheral Na+ channel 1 (SCN9A, NENA, PN1)
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Function
- mediates voltage-dependent Na+ permeability of excitable membranes
- assumes opened or closed conformation in response to voltage difference across membrane
- forms a Na+-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient
- tetrodotoxin-sensitive Na+ channel isoform
- plays a role in pain mechanisms, especially in the development of inflammatory pain (putative)
- ubiquitinated by NEDD4L; which may promote its endocytosis
- does not seem to be ubiquitinated by NEDD4 (putative)
- the Na+ channel consists of a large polypeptide & 2-3 smaller ones interacts with NEDD4 & NEDD4L (putative)
Structure
- large polypeptide contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & 1 positively charged segment (S4).
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every 3rd position
- belongs to the Na+ channel family
- contains 1 IQ domain
Compartment
Alternative splicing
named isoforms=3
Expression
- expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body
- expressed in smooth muscle cells, MTC cell line & C-cell carcinoma
- isoform 1 is expressed preferentially in the central & peripheral nervous system while isoform 2 is expressed preferentially in the dorsal root ganglion
Pathology
- defects in SCN9A are the cause of
More general terms
- transmembrane 24 protein
- voltage-dependent Na+ channel protein alpha subunit
- glycoprotein
- phosphoprotein
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q15858.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCN9A
- ↑ Wikipedia; Note: SCN9A entry http://en.wikipedia.org/wiki/SCN9A
- ↑ Protein Spotlight; Silent pain - Issue 102, February 2009 http://www.expasy.org/spotlight/back_issues/sptlt102.shtml
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6335
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6335
- OMIM: https://mirror.omim.org/entry/133020
- OMIM: https://mirror.omim.org/entry/167400
- OMIM: https://mirror.omim.org/entry/243000
- OMIM: https://mirror.omim.org/entry/603415
- UniProt: http://www.uniprot.org/uniprot/Q15858.html