ATPase family AAA domain-containing protein 5 (chromosome fragility-associated gene 1 protein, ATAD5, C17orf41, FRAG1)

Function

• role in DNA damage response
• involved in a RAD9A-related damage checkpoint
• modulates RAD9A interaction with BCL2 & thereby induces DNA damage-induced apoptosis
• interacts with RB1 predominantly in G1 phase via its LXCXE motif
• interacts with RAD9A in growing cells
• interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents
• phosphorylated upon DNA damage, probably by ATM or ATR
• ATR may stimulate the RAD9A dissociation

Structure

belongs to the AAA ATPase family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7991
• UniProt: http://www.uniprot.org/uniprot/Q96QE3.html