Ca+2-binding & coiled-coil domain-containing protein 1 (calphoglin, sarcoma antigen NY-SAR-3, coiled-coil coactivator protein, CALCOCO1, KIAA1536, PP13275, UNQ2436/PRO4996)

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Function

coactivator for aryl hydrocarbon & nuclear receptors
recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, including NCOA2
during estrogen receptor-activation, acts synergistically in combination with other NCOA2-binding proteins, including EP300, CREBBP & CARM1
role in transcriptional activation of target genes in the Wnt/CTNNB1 pathway
secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1
coactivator for nuclear receptors & LEF1/CTNNB1
involves differential utilization of 2 different activation regions (putative)
seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG).
probably functions as component of the calphoglin complex
interacts with the bHLH-PAS domains of GRIP1, AHR & ARNT
interacts with CTNNB1 via both its N- & C-terminal regions
interacts with EP300 (putative)

C-terminal activation region (AD) is used for downstream signaling; seems to be essential for coactivator function with nuclear receptors & with the aryl hydrocarbon receptor (putative)
N-terminal activation region (AD) is necessary & sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1; contains a EP3000 binding region which is important for synergistic cooperation (putative)
recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators
belongs to the CALCOCO1 family