phosphofurin acidic cluster sorting protein 1 (PACS-1, PACS1, KIAA1175)

Function

• coat protein with role in localization of trans-Golgi network membrane proteins with acidic cluster sorting motifs
• controls the endosome-to-Golgi trafficking of furin & mannose-6-phosphate receptor by connecting the acidic-cluster- containing cytoplasmic domain with adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits
• interacts with AP-1 & AP-3 but not with AP- 2
• forms a ternary complex with furin & AP-1

Compartment

trans-Golgi network

Alternative splicing

named isoforms=2

Pathology

• role in HIV-1 nef-mediated removal of MHC-I from the cell surface to the trans-GOLGI
• combines with Nef to usurp the ARF6 endocytic pathway by a PI3K-dependent process to remove cell surface MHC-I molecules

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607492
• UniProt: http://www.uniprot.org/uniprot/Q6VY07.html