HA3/AP3 adaptor complex

Function

• adaptor complex, not clathrin-associated
• facilitates budding of vesicles from Golgi
• role in trafficking to lysosomes

Structure

heterotetramer of:

• 2 large adaptins (AP3D1 & AP3B2 or AP3B1)
• 1 medium adaptin (AP3M1 or AP3M2)
• 1 small adaptin (AP3S1 or AP3S2)

Compartment

Golgi, vesicles

Expression

• AP3B2 expression is restricted to the central nervous system

More general terms

• HA/AP adaptor complex