AP-3 complex subunit beta-1; adapter-related protein complex 3 subunit beta-1; adaptor protein complex AP-3 beta-1 subunit; beta3A-adaptin; clathrin assembly protein complex 3 beta-1 large chain (AP3B1, ADTB3A)
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Function
- subunit of non-clathrin- & clathrin-associated adaptor protein complex 3 (AP-3)
- phosphorylated on Ser
Structure
- belongs to the adaptor complexes large subunit family
Compartment
- Golgi, cytoplasmic vesicle
- clathrin-coated vesicle membrane
- peripheral membrane, cytoplasmic side
- component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (putative)
Alternative splicing
named isoforms=2
Expression
ubiquitously expressed
Pathology
- defects in AP3B1 are associated with Hermansky-Pudlak syndrome 2
More general terms
Additional terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/O00203.html
- ↑ AP3B1base; Note: AP3B1 mutation db http://bioinf.uta.fi/AP3B1base/
- ↑ Mutations of the ADTB3A gene RetinaInternational's Scientific Newsletter http://www.retina-international.com/sci-news/adtb3mut.htm
- ↑ Albinism database (ADB); AP3B1 mutations http://albinismdb.med.umn.edu/hps2mut.htm
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=AP3B1