membrane-associated phosphatidylinositol transfer protein 1; Drosophila retinal degeneration B homolog; phosphatidylinositol transfer protein, membrane-associated 1; PITPnm 1; Pyk2 N-terminal domain-interacting receptor 2; NIR-2 (PITPNM1, DRES9, NIR2)

Function

• regulates RhoA activity
• cytoskeleton remodeling
• completion of cytokinesis
• regulates diacylglycerol levels in the Golgi apparatus
• binds phosphatidyl inositol phosphates
• transfer of phosphatidylinositol & phosphatidylcholine between membranes
• structure of endoplasmic reticulum & Golgi apparatus
• protein export from the endoplasmic reticulum & Golgi
• binds Ca+2
• interactions:
  • PIK4CA
  • PTK2B via its C-terminus
  • RhoA, higher affinity for inactive, GDP-bound form
  • CDC2-phosphorylated form interacts with PLK1
  • VAPB
• phosphorylated on multiple sites by CDC2 at onset of mitosis
• phosphorylation facilitates dissociation from the Golgi
• phosphorylated on Thr upon treatment with oleic acid
• phosphorylated on Tyr by PTK2B

Structure

• belongs to the Ptdins transfer protein family, PI transfer class IIA subfamily
• contains 1 DDHD domain

Compartment

• cytoplasm
• Golgi stacks
• endoplasmic reticulum in interphase cells
• dissociates from the Golgi early on in mitosis
• localizes to the cleavage furrow & midbody during cytokinesis
• lipid droplets

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• membrane-associated phosphatidylinositol transfer protein
• phosphoprotein

Additional terms

• phosphatidylinositol (phosphoinositide, 1-phosphatidyl-1D-myo-inositol)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9600
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9600
• OMIM: https://mirror.omim.org/entry/608794
• UniProt: http://www.uniprot.org/uniprot/O00562.html