phosphoinositide-4-kinase alpha (Ptdins-4-kinase alpha, PI4K-alpha, PI4KA)

Function

• acts on phosphatidylinositol (Ptdins) in the 1st committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (IP3)
• this is a type II Ptdins-4-kinase activated by detergents such as triton
• inhibited by adenosine

ATP + 1-phosphatidyl-1D-myo-inositol
                <-->
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Structure

• belongs to the PI3/PI4-kinase family. type III PI4K subfamily
• contains 1 PI3K/PI4K domain

Alternative splicing

named isoforms=2

Expression

• expressed ubiquitously
• highest levels in placenta & brain

little or no expression in lung, liver, pancreas, testis or leukocytes

More general terms

• phosphoinositide-4-kinase

Database

• UniProt: http://www.uniprot.org/uniprot/P42356.html
• OMIM: https://mirror.omim.org/entry/600286
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5297