cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein (CDC5L, KIAA0432, PCDC5RP)

Function

• DNA-binding protein involved in cell cycle control
• may act as a transcription activator
• also seems to be involved in the second catalytic step of pre-mRNA splicing
• phosphorylated; which enhances interaction with PPP1R8
• interacts with DAPK3 (putative)
• binds to DNA
• binds to adeno-pre-mRNA in an ATP-stimulated manner
• belongs to the spliceosome complex
• part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 & CCAP6
• interacts with PLRG1, Lodestar/TTF2, & NIPP1/PPP1R8
• identified in the spliceosome C complex

Structure

• homodimer
• belongs to the CEF1 family
• contains 2 HTH myb-type DNA-binding domains

Compartment

• nuclear speckle, cytoplasm
• may shuttle between cytoplasm & nucleus

Expression

• ubiquitously expressed in both fetal & adult tissues

Pathology

• chromosomal translocation t(6;19)(p21;q13.1) involving CDC5L with USF2 is found in multicystic renal dysplasia

More general terms

• DNA-binding protein
• phosphoprotein
• oligomerizing protein

Component of

• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=988
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:988
• OMIM: https://mirror.omim.org/entry/602868
• UniProt: http://www.uniprot.org/uniprot/Q99459.html