transcription termination factor 2 (RNA polymerase 2 termination factor, transcription release factor 2, factor 2, F2, HuF2, Lodestar homolog, TTF2)

Function

• dsDNA-dependent ATPase
• transcription termination factor
• couples ATP hydrolysis with removal of RNA polymerase 2 from DNA template
• role in mitotic transcription repression (putative)
• role in pre-mRNA splicing (putative)
• interacts with CDC5L
• component of spliceosome

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• cytoplasm, nucleus
• cytoplasmic during interphase
• relocates to the nucleus as cells enter mitosis

Alternative splicing

named isoforms=2

More general terms

• DEAH box ATP-dependent helicase
• helicase (DNA unwinding protein, DNA untwisting protein)

Component of

• spliceosome

Database

• OMIM: https://mirror.omim.org/entry/604718
• UniProt: http://www.uniprot.org/uniprot/Q9UNY4.html