tensin-3; tumor endothelial marker 6; tensin-like SH2 domain-containing protein 1 (TNS3, TEM6, TENS1, TPP)

Function

• may be involved in cell migration & bone development
• EGF promotes the interaction with EGFR
• interacts with PTK2 & BCAR1
• tyrosine phosphorylation is required for these interactions
• EGF induces tyrosine phosphorylation (dose-dependent)

Structure

• contains 1 C2 tensin-type domain
• contains 1 phosphatase tensin-type domain
• contains 1 SH2 domain

Compartment

cell junction, focal adhesion

Alternative splicing

named isoforms=4

Expression

• expressed in umbilical vein endothelial cells, epithelial cells, & fibroblasts cells (at protein level)
• expressed in thyroid, kidney & placenta > heart, skeletal muscle, spleen, liver, & lung

Pathology

• expressed in tumor endothelial cells
• expression seems to be down-regulated in thyroid tumor tissues & in anaplastic carcinomas

More general terms

• SH2 domain-containing protein
• tumor endothelial marker
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606825
• UniProt: http://www.uniprot.org/uniprot/Q68CZ2.html