hypoxia-inducible factor 1-alpha inhibitor; factor inhibiting HIF-1; FIH-1; hypoxia-inducible factor asparagine hydroxylase (HIF1AN, FIH1)

Function

• hydroxylates HIF-1 alpha at Asp-803 in the C-terminal transactivation domain (CAD)
• functions as an oxygen sensor &, under normoxic conditions, hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator
• role in transcriptional repression through interaction with HIF1A, VHL & histone deacetylases
• interacts with VHL & HIF1A
• part of a complex with VHL, HIF1A & HDAC1 or HDAC2 or HDAC3

peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2

Cofactor: iron

Structure

• homodimer
• contains 1 JmjC domain

Compartment

nucleus (putative)

More general terms

• hydroxylase; monooxygenase
• metalloprotein

Additional terms

• hypoxia-inducible factor 1 alpha; ARNT interacting protein; member of PAS protein 1 (HIF1A, MOP1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55662
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55662
• OMIM: https://mirror.omim.org/entry/606615
• UniProt: http://www.uniprot.org/uniprot/Q9NWT6.html