protein naked cuticle homolog 2 (hNkd2, Naked-2, NKD2)

Function

• cell autonomous antagonist of the canonical Wnt signaling pathway
• may activate a second Wnt signaling pathway that controls planar cell polarity (putative)
• required for processing of TGFA & for targeting of TGFA to the basolateral membrane of polarized epithelial cells
• interacts with DVL1, DVL2, DVL3 & PPP2R3A
• interacts with TGFA

Structure

• belongs to the NKD family
• contains 1 EF-hand domain

Compartment

• cell membrane, cytoplasm, cytoplasmic vesicle

Alternative splicing

named isoforms=2

Expression

• expressed in kidney, lung, pancreas & spleen
• expressed in fetal kidney & lung

More general terms

• Ca+2 binding protein
• myristoylated protein

Database

• OMIM: https://mirror.omim.org/entry/607852
• UniProt: http://www.uniprot.org/uniprot/Q969F2.html