segment polarity protein dishevelled homolog DVL-2; dishevelled-2; DSH homolog 2 (DVL2)

Function

• may play a role in the signal transduction pathway mediated by multiple Wnt genes
• interacts through its PDZ domain with the C-terminal regions of VANGL1 & VANGL2 (putative)
• interacts with DIXDC1 & Rac
• interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL2
• endocytosis of frizzled 4 is dependent on wnt 5A & requires beta-arrestin 2; frizzled 4 binding to dishevelled 2 recruits beta-arrestin 2

Structure

• belongs to the DSH family
• contains 1 DEP domain
• contains 1 DIX domain
• contains 1 PDZ domain (DHR domain)

Compartment

• cytoplasm

More general terms

• dishevelled family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1856
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1856
• OMIM: https://mirror.omim.org/entry/602151
• UniProt: http://www.uniprot.org/uniprot/O14641.html