beta-arrestin-2; arrestin beta-2 (ARRB2 ARB2 ARR2)

^[1]^[2]^[3]^[4]^[5]

Function

regulates beta-adrenergic receptor function
beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate Gs proteins
binds to phosphorylated C-terminus of TGF-beta receptor 3, promotes endocytosis of TGFBR3 & downregulates TGF-beta signaling^[2]
Frizzled 4 binding to protein kinase C phosphorylated dishevelled 2 recruits beta-arrestin 2; further stimulation by wnt5A is required for endocytosis via clathrin coated pits^[1]

belongs to the arrestin family

mice without functional beta-arrestin-2 are 3 times more sensitive to the analgesic effect of morphine than normal mice
additionally the effects of morphine last 3 times as long
these effects are mediated via the mu-opioid receptor (as they are nullified by naloxone)

↑ ^1.0 ^1.1 Chen W et al Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 301:1391-4, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12958364
↑ ^2.0 ^2.1 Chen W et al Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 301:1394-7, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12958365
↑ Journal Watch 20(3):27, 2000
↑ Bohn LM et al Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286:2495, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10617462
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=409