dixin (DIX domain-containing protein 1, coiled-coil protein DIX1, coiled-coil-DIX1, DIXDC1, CCD1, KIAA1735)

Function

• positive effector of the Wnt signaling pathway
• regulates JNK activation by AXIN1 & DVL2
• isoform 1 but not isoform 2 binds filamentous actin
• interacts with complex composed of DVL2 & Rac
• interacts with AXIN1; competes with MAP3K1
• interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1

Structure

• belongs to the DIXDC1 family
• contains 1 CH domain (calponin-homology domain)
• contains 1 DIX domain
• coiled-coil domain mediates interaction with MAP3K4 & i inhibition of AXIN1-mediated JNK activation through MAP3K4
• DIX domain mediates interaction with AXIN1 & inhibition of AXIN1-mediated JNK activation through MAP3K1, mediates interaction with DVL2 (putative)

Compartment

• isoform 1: cell junction, focal adhesion
• isoform 2: cytoplasm
• isoform 1 is associated with actin stress fiber at the filament ends

Alternative splicing

named isoforms=4

Expression

• ubiquitously expressed with higher expression in cardiac & skeletal muscles

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q155Q3.html