segment polarity protein dishevelled homolog DVL-3; dishevelled-3; DSH homolog 3 (DVL3 KIAA0208)

Function

• may play a role in the signal transduction pathway mediated by multiple Wnt genes
• interacts (via the PDZ domain) with the C-terminal regions of VANGL1 & VANGL2 (putative)
• interacts with LRRFIP2 via region containing both PDZ domain & DEP domain; DIX domain may inhibit this interaction

Structure

• belongs to the DSH family
• contains 1 DEP domain
• contains 1 DIX domain
• contains 1 PDZ domain (DHR domain)

Compartment

• cytoplasm (putative)

More general terms

• dishevelled family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1857
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1857
• OMIM: https://mirror.omim.org/entry/601368
• UniProt: http://www.uniprot.org/uniprot/Q92997.html