protein naked cuticle homolog 1 (hNkd1, hNkd, naked-1, NKD1, NKD, PP7246)

Function

• cell autonomous antagonist of the canonical Wnt signaling pathway
• may activate a second Wnt signaling pathway that controls planar cell polarity
• interacts with DVL1, DVL2, DVL3 & PPP2R3A

Structure

• belongs to the NKD family
• contains 1 EF-hand domain

Compartment

cell membrane (putative), cytoplasm

Expression

• expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine & spleen
• expressed in fetal brain, kidney, liver & lung
• induced by activation of the Wnt signaling pathway

More general terms

• Ca+2 binding protein
• myristoylated protein

Database

• OMIM: https://mirror.omim.org/entry/607851
• UniProt: http://www.uniprot.org/uniprot/Q969G9.html