regulator of G-protein signaling 12 (RGS12)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 1 Goloco domain
• contains 1 PDZ domain (DHR domain)
• contains 1 PID domain
• contains 2 RBD (Ras-binding) domains
• contains 1 RGS domain

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

isoform 3 is brain specific

More general terms

• regulator of G-protein signaling
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6002
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6002
• OMIM: https://mirror.omim.org/entry/602512
• UniProt: http://www.uniprot.org/uniprot/O14924.html