Tumor necrosis factor, alpha-induced protein 8 (head & neck tumor & metastasis-related protein, TNF-induced protein GG2-1, SCC-S2, NF-kappa B-inducible DED-containing protein, NDED, MDC-3.13, TNFAIP8)
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Function
- negative mediator of apoptosis
- role in tumor progression
- suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage & caspase-3 activation
Structure
belongs to the TNFAIP8 family
Compartment
Alternative splicing
named isoforms=3
Expression
- expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow, placenta
- expressed at high levels both in various tumor tissues, unstimulated & cytokine-activated cultured cells
- expressed at low levels in spinal cord, ovary, lung, adrenal glands, heart, brain, testis, skeletal muscle
- expressed at high levels in the fetal liver, lung & kidney
- induced by nuclear factor-KB (NF-KB) & TNF
- induction by TNF depends upon activation of NF-KB