rhophilin-2 (GTP-Rho-binding protein 2, 76 kD RhoB effector protein, p76RBE, RHPN2)

Function

• binds specifically to GTP-Rho
• may function in a Rho pathway to limit stress fiber formation &/or increase turnover of F-actin structures in the absence of high levels of RhoA activity
• interacts with GTP-bound RhoA & RhoB
• interacts with both GTP- & GDP-bound RhoA (controversy)
• interacts with KRT18

Structure

• contains 1 BRO1 domain
• contains 1 PDZ domain (DHR domain)
• contains 1 REM repeat (Hr1 repeat)

Compartment

cytoplasm, perinuclear region

Expression

• widely expressed
• highly expressed in prostate, trachea, stomach, colon, thyroid, pancreas
• expressed at lower level in brain, spinal cord, kidney, placenta, liver
• induced by thyrotropin (TSH), regulated by the cAMP pathway

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IUC4.html