RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2, partner of RalBP1, REPS2, POB1)

Function

• role in growth factor signaling through its influence on the Ral signaling pathway
• interacts with DDEF1 & this complex can bind paxillin
• may form a ternary complex with RALBP1 & DDEF1
• interacts with RALBP1 & GRB2
• binding to RALBP1 does not affect the Ral-binding activity of the latter
• forms ternary complex with activated Ral & RALBP1
• binds EPN1
• EGF stimulates phosphorylation on Tyr & induces complex formation with EGF receptor via adapter protein, i.e. GRB2

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in cerebrum, cerebellum, lung, kidney, testis > kidney

Pathology

• relatively highly expressed in androgen-dependent as compared with androgen-independent prostate cancer cell lines
• isoform 2 is down-regulated during progression of prostate cancer

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/300317
• UniProt: http://www.uniprot.org/uniprot/Q8NFH8.html