melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4; preferentially expressed antigen of melanoma (PRAME MAPE OIP4)

Function

• transcriptional repressor, inhibiting signaling of retinoic acid through the retinoic acid receptors RARA, RARB & RARG
• prevents retinoic acid-induced cell proliferation arrest, differentiation & apoptosis
• interacts with RARA (via the ligand-binding domain)
• interacts with EZH2
  • interaction required to repress RAR signaling

Structure

• belongs to the PRAME family
• contains 4 LRR repeats (leucine-rich repeats)

Compartment

• nucleus (probable)
• cell membrane

Expression

• expressed in testis
• detected in samples of kidney, brain & skin

Pathology

• PRAME is a tumor antigen recognized by cytolytic T-cells

More general terms

• other protein

Additional terms

• melanoma

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23532
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23532
• OMIM: https://mirror.omim.org/entry/606021
• UniProt: http://www.uniprot.org/uniprot/P78395.html