NF-kappa-B-repressing factor; NFkB-repressing factor; protein ITBA4; transcription factor NRF (NKRF, ITBA4, NRF)

Function

• interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes
• role in the constitutive silencing of the interferon-beta promoter, independently of the virus-induced signals
• role in the inhibition of the basal & cytokine-induced iNOS promoter activity
• also involved in the regulation of IL-8 transcription
• interacts with NF-kappa-B

Structure

• contains 1 G-patch domain
• contains 1 R3H domain

Compartment

nucleus, nucleolus

Expression

• widely & constitutively expressed
• low expression in colon, peripheral blood lymphocytes, lung & kidney

More general terms

• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55922
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55922
• OMIM: https://mirror.omim.org/entry/300440
• UniProt: http://www.uniprot.org/uniprot/O15226.html