interferon-inducible protein AIM2; absent in melanoma 2 (AIM2)

Function

• tumor suppressor
• may act by repressing NF-kappa-B transcriptional activity
• homodimer

Structure

• belongs to the HIN-200 family
• contains 1 DAPIN domain
• contains 1 HIN-200 domain

Compartment

nucleus

Expression

• expressed in spleen, small intestine, peripheral blood leukocytes, & testis
• induced by IFNG/IFN-gamma

Pathology

• defects in AIM2 may be a cause of microsatellite instabilty in colon cancer

More general terms

• nuclear protein

Additional terms

• melanoma

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9447
• OMIM: https://mirror.omim.org/entry/604578
• UniProt: http://www.uniprot.org/uniprot/O14862.html