microsatellite or variable number of tandem repeat (VNTR)
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Introduction
Microsatellite or variable number of tandem repeats (VNTR) are reiterated mono- & dinucleotide elements scattered throughout the genome[1]. They are stably inherited with a low rate of mutation. A PCR reaction using 2 primers that bracket a micro- satellite or VNTR produces a different pair of DNA bands from different individuals[2]. One of these bands contains the VNTR inherited from the individual's mother & the other contains the VNTR inherited from the father. A large set of DNA bands obtained from different PCR reactions, each of which amplifies DNA from a different VNTR, can serve as a 'fingerprint' in the identification of individuals.
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References
- ↑ 1.0 1.1 Karran P. Appropriate partners make good matches. Science. 1995 Jun 30;268(5219):1857-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7604258
- ↑ 2.0 2.1 Molecular Biology of the Cell, 3rd ed. Alberts, Bray, Lewis, Raff, Roberts & Watson (eds) Garland Publishing, New York 1994, pg 303
- ↑ Brentnall Am J Pathol 147:561 1995