TNFAIP3-interacting protein 1; HIV-1 Nef-interacting protein; Nef-associated factor 1; Naf1; Nip40-1; virion-associated nuclear shuttling protein; VAN; hVAN (TNIP1, KIAA0113, NAF1)

Function

• interacts with zinc finger protein A20/TNFAIP3
• inhibits TNF-induced NF-kappa-B-dependent gene expression
• increases cell surface CD4(T4) antigen expression.
• interacts with HIV-1 matrix protein
• packaged into virions
• overexpression can inhibit viral replication
• NAF1-alpha interacts directly with ERK2
• overexpression of NAF1
  • suppressed ERK2 nuclear translocation following activation
  • attenuated EGF/ERK2 signaling
  • increased expression of CD4

Compartment

• cytoplasm, nucleus
• shuttles between the nucleus & cytoplasm (CRM1-dependent)

Alternative splicing

named isoforms=2; NAF1-alpha & NAF-1 beta

Expression

• ubiquitous
• expressed in peripheral blood lymphocytes, spleen, skeletal muscle > brain

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10318
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10318
• OMIM: https://mirror.omim.org/entry/607714
• UniProt: http://www.uniprot.org/uniprot/Q15025.html