arfaptin
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Introduction
- 3 human isoforms identified:
- arfaptin 1/Por2
- rfaptin 2/Por1
- rfaptin 1b.
Function
- arfaptin is an inhibitor of Arf1-dependent phospholipase D activity & implicated in mediating cross-talk between Rac & Arf small GTPases
- arfaptin binds to GTP-bound Arf1 & Arf6
More general terms
More specific terms
- Arfaptin-1; ADP-ribosylation factor-interacting protein 1 (ARFIP1, POR2)
- Arfaptin-2; ADP-ribosylation factor-interacting protein 2; partner of RAC1; protein POR1 (ARFIP2, POR1)
References
- ↑ Tarricone C et al. The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. Nature 411:215-9 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11346801