Arfaptin-2; ADP-ribosylation factor-interacting protein 2; partner of RAC1; protein POR1 (ARFIP2, POR1)

Function

• putative target protein of ADP-ribosylation factor
• involved in membrane ruffling
• interacts with RAC1 by binding directly to it
• specifically binds to GTP-bound ARF1 & ARF6, but binds to RAC1-GTP & RAC1-GDP with similar affinities

Structure

• contains 1 AH domain

More general terms

• arfaptin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23647
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23647
• OMIM: https://mirror.omim.org/entry/601638
• UniProt: http://www.uniprot.org/uniprot/P53365.html