Arfaptin-1; ADP-ribosylation factor-interacting protein 1 (ARFIP1, POR2)

Function

• putative target protein of ADP-ribosylation factor
• interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, & also to ARF1
• binds with lower affinity to ARF5 & with very little affinity to ARF6

Structure

• contains 1 AH domain

Alternative splicing

• named isoforms=2

Expression

• ubiquitously expressed
• higher levels in liver, pancreas, placenta, skeletal muscle & heart

More general terms

• arfaptin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27236
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27236
• OMIM: https://mirror.omim.org/entry/605928
• UniProt: http://www.uniprot.org/uniprot/P53367.html