tyrosine kinase CTK; protein kinase HYL; hematopoietic consensus tyrosine-lacking kinase; protein kinase MATK; megakayrocyte-associated protein kinase (MATK, CTK, HYL)

Function

• role in the signal transduction of hematopoietic cells (putative)
• may regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory Tyr which acts as a negative regulatory site
• may play an inhibitory role in the control of T-cell proliferation
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, CSK subfamily
• contains 1 protein kinase domain
• contains 1 SH2 domain
• contains 1 SH3 domain

Compartment

cytoplasm

Expression

• expressed in various myeloid cell lines
• detected in brain & lung

More general terms

• tyrosine kinase (protein tyrosine kinase, PTK)

Database

• UniProt: http://www.uniprot.org/uniprot/P42679.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4145
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4145
• OMIM: https://mirror.omim.org/entry/600038