cyclin-dependent kinase-20 (CDK20); CDK-activating kinase p42; CAK-kinase p42; cell cycle-related kinase; cell division protein kinase 20; cyclin-dependent protein kinase H; cyclin-kinase-activating kinase p42 (CCRK, CDCH)

Function

• required for high-level SHH responses in the developing neural tube
• together with BROMI, controls structure of primary cilium by coordinating assembly of the ciliary membrane & axoneme, allowing GLI2 to be properly activated in response to SHH signaling (putative)
• involved in cell growth
• activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating Thr-160
• interacts with BROMI (putative)

Structure

• monomer
• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

• nucleus. cytoplasm (putative)
• cell projection, cilium (putative)

Alternative splicing

named isoforms=3

More general terms

• cyclin-dependent kinase (CDK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23552
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23552
• OMIM: https://mirror.omim.org/entry/610076
• UniProt: http://www.uniprot.org/uniprot/Q8IZL9.html